Pompholyx may refer to:
Pompholyx, certain eczema, see dyshidrosis
Pompholyx (rotifer), a genus of rotifers in the family Testudinellidae
Pompholyx, a genus of insects in the family Pneumoridae, synonym of Prostalia
Pompholyx, a genus of fungi in the family Sclerodermataceae, synonym of Scleroderma